Direct methods for detection of protein S-nitrosylation
نویسندگان
چکیده
منابع مشابه
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15 صفحه اولProtein S-nitrosylation and cardioprotection.
Nitric oxide (NO) plays an important role in the regulation of cardiovascular function. In addition to the classic NO activation of the cGMP-dependent pathway, NO can also regulate cell function through protein S-nitrosylation, a redox dependent, thiol-based, reversible posttranslational protein modification that involves attachment of an NO moiety to a nucleophilic protein sulfhydryl group. Th...
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S-Nitrosylation is a redox-mediated posttranslational modification that regulates protein function via covalent reaction of nitric oxide (NO)-related species with a cysteine thiol group on the target protein. Under physiological conditions, S-nitrosylation can be an important modulator of signal transduction pathways, akin to phosphorylation. However, with aging or environmental toxins that gen...
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Chemical modification of protein thiols has profound effects on the structure and catalytic activity of proteins. These post-translational modifications are often transient in nature, and therefore characterization of them can be elusive, especially in the case of S-nitrosothiols. Many of the methods discussed here involve a trapping mechanism where the modified thiol is selectively reduced and...
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Helmholtz Zentrum München, Research Unit Environmental Simulation (E.V., V.V., A.G., J.-P.S.), Institute of Biochemical Plant Pathology (C.L., J.D.), and Research Unit Protein Science (J.M.-P., S.M.H.), D–85764 Neuherberg, Germany; Institute of Plant Physiology and Genetics, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria (V.V.); and Institute for Microbiology, Ernst-Moritz-Arndt University...
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ژورنال
عنوان ژورنال: Methods
سال: 2013
ISSN: 1046-2023
DOI: 10.1016/j.ymeth.2013.04.018